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MRC Biostatistics Unit Short Courses

MRC Biostatistics Unit Short Courses

Genetics in Drug Development, 24-28 November 2025

Genetics in Drug Development, 24-28 November 2025

Description

The majority of biologic and small molecule drugs perturb protein targets to exert their effects. With the recent explosion in the availability of large-scale genetic association data, it is increasingly feasible to identify genetic variants that proxy the effect of perturbing a protein drug target. Leveraging such genetic data thus offers an efficient and cost-effective approach for identifying drug targets and studying their effects.

This short course “Genetics in drug development” will provide theoretical and practical advice on using genetic data to:
1.    Identify drug targets
2.    Investigate the effects of drug target perturbation for different indications
3.    Explore potential adverse effects and repurposing potential for drug targets
4.    Identify biomarkers to explore drug efficacy in early stage clinical trials
5.    Identify population subgroups for which drug effects may vary
6.    Explore interactions between different drugs and exposures


University of Cambridge Students and Staff, whose department will be covering the participation cost, please raise a Purchase Order (or contact a member of your department who can assist with this) and send a PDF of the Purchase Order to burgess-group-admin@mrc-bsu.cam.ac.uk .  You will then be sent the passcode which you will need to use along with the Purchase Order number to complete registration below, selecting the 'UoC Student/Staff Registration' option. 

Attendee CategoryCost   
1. External Standard Registration£350.00[Read More]
2. UoC Student/Staff Registration: Internal Cross-Charge £350£0.00[Read More]
Mendelian Randomization Course, 03-21 November 2025

Mendelian Randomization Course, 03-21 November 2025

Description

The course comprises four half-days’ worth of content plus the final hackathon, and will take place over 3 weeks (plus a preliminary week 0). It consists of some on-demand pre-recorded content and some timetabled (live) content. The first day of Week 1 will be Monday 3rd November 2025. All the core content of the course is pre-recorded - live sessions are not compulsory to attend, but are supplementary to the core content. They represent a chance to engage with the course tutors. Several of the live sessions will be recorded.

Each half-day can be done whenever is convenient. A half-day of content includes three pre-recorded talks (around 20-30 minutes each) and one practical session (around 1-1.5 hour). Each of the three computer practicals should be performed individually, but there is an associated live drop-in session to come and ask questions. There is also a recorded debrief session that runs through the practical content. In terms of live content, in addition to the practical drop-in sessions, paper discussion, and hackathon, there is also a question and answer session each week to ask your questions. Questions can be asked during the week on a dedicated Slack channel, or you can ask questions live (Q+A sessions will be recorded).


University of Cambridge Students and Staff, whose department will be covering the participation cost, please raise a Purchase Order (or contact a member of your department who can assist with this) and send a PDF of the Purchase Order to burgess-group-admin@mrc-bsu.cam.ac.uk .  You will then be sent the passcode which you will need to use along with the Purchase Order number to complete registration below, selecting the 'UoC Student/Staff Registration' option. 

Attendee CategoryCost   
1. UoC Student/Staff Registration£0.00[Read More]
2. External Student Registration£200.00[Read More]
3. External Academic/Non-profit Registration£380.00[Read More]
4. Private Sector/Commercial Registration£500.00[Read More]
Efficient Adaptive Designs for Phase I Dose-Finding and Dose-Optimisation Studies, 24-26 Sep 2025

Efficient Adaptive Designs for Phase I Dose-Finding and Dose-Optimisation Studies, 24-26 Sep 2025

Description

Early phase trials are recognised to have a major impact on later phase confirmatory trials. This course presents state of the art methodology for Phase I dose-finding and dose-optimisation studies that are delivered via a mixture of lectures, practical sessions, and discussions. The topics will include:
•    Model-based and model-free Phase I dose-finding single-agent designs;
•    Dose-optimisation strategies
•    Phase I dose-findings designs for dual-agent and dose-schedules trials
•    Phase I/II designs for cytotoxic drugs;
•    Randomised dose-escalations trials;
•    Inclusion of covariates into Phase I dose-escalation;


Among other methods we will learn about model-based dose-escalation in-patients studies (such as Continual Reassessment Method [CRM], Bayesian logistic regression model [BLRM], Escalation with Overdose Control [EWOC]), model-free and model-assisted designs, their extensions for dual-agent and dose-schedule trials, and implementation of these designs in a software (specifically, R).


The course focuses on in-person dose-finding studies and will cover several therapeutic areas, including oncology, infectious diseases, cardiovascular diseases, and opioids detoxification. 


University of Cambridge Students and Staff, whose department will be covering the participation cost, please raise a Purchase Order (or contact a member of your department who can assist with this) and send a PDF of the Purchase Order to sharon.dippenaar@mrc-bsu.cam.ac.uk.  You will then be sent the passcode which you will need to use along with the Purchase Order number to complete registration below, selecting the 'UoC Student/Staff Registration' option. 

Attendee CategoryCost   
1. External Commercial/Industry Registration£1000.00[Read More]
2. External Academic/Public sector/Charity Registration£690.00[Read More]
3. External Postgraduate Student Registration£450.00[Read More]
4. UoC Student/Staff Registration: Internal Crosscharge£0.00[Read More]

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