Response-Adaptive Methods for Clinical Trials - In Person Course, 23-24 October 2024Info Location Contact More Info Event Information
DescriptionRecent high-profile clinical trials have used a response-adaptive procedure as the way to implement an “adaptive” experiment. Such response-adaptive designs allow a variety of mid-trial modifications to be made to the trial so that the accumulating data guides investigators to the most appropriate form of evaluation (e.g. they can be used for arm selection, arm dropping, or simply to assign more patients on average to a superior treatment where possible). While offering great flexibility during the trial, they require specialised approaches for both the trial design and analysis. Consequently, there is growing interest amongst clinical researchers and the clinical trials community in the use of these methods for conducting either early or late phase trials that more efficiently or more accurately balance competing goals, while gathering sufficient evidence to reach a convincing conclusion. University of Cambridge Students and Staff, whose department will be covering the participation cost, please contact Admin Team at [email protected] to arrange an internal crosscharge and obtain an access passcode to use this booking system. PO number and Access Passcode is required during the booking process.
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More InformationIn this course, we will start from the definition of response-adaptive designs and consider several important aspects of their design and analysis. These concepts will be delivered through a mixture of lectures, practical sessions, and discussions. 1. Types of response-adaptive allocation procedures 2. Design and analysis considerations 3. Implementing response-adaptive designs (targeting an unequal ratio) 4. Discussion of case studies. Throughout the course, examples of trials implemented in practice will be used to illustrate the methodology. The workshop will involve practical sessions in R on design implementations and discussions on the practical aspects. The course is planned to have a 1.5 day programme. This would probably take 10-5 (23 Oct) and 9-1pm (24 Oct) but the exact timings will be confirmed later.
Course objectives Identify design and analysis considerations specific to response-adaptive designs, including how to target unequal allocation ratios Explore and compare the performance of a range of response-adaptive designs via simulation in R To identify key case studies of clinical trials that use response-adaptive methods in practice
Course tutors Intended audience
For further course details, please visit http://www.mrc-bsu.cam.ac.uk/training/short-courses/
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